Summit Therapeutics

New analyses show that Ivonescimab achieved a statistically significant benefit in overall survival versus Keytruda in Phase-III data. Partner Akeso successfully completed the HARMONi-2 study, reinforcing the potential of the lead compound. The results reduce development risk and strengthen the chances for future approvals and the company’s global market position. » More on finanzen.net

Summit Therapeutics shares rose about 4.8% premarket after partner Akeso released positive overall survival data from the Phase‑III HARMONi‑2 study of ivonescimab in non‑small cell lung cancer. The monotherapy showed a statistically significant advantage over pembrolizumab, but concrete metrics such as hazard ratio or median survival times were not disclosed. Ivonescimab is already approved and commercially available in China; in Summit’s licensed territories, including the USA and Europe, the drug is still under investigation. An analyst left the rating at neutral pending further details. » More on de.investing.com

Summit Therapeutics reports positive phase-3 data from the global HARMONi study: the combination of Ivonescimab plus chemotherapy increased median progression-free survival in EGFR-mutated, advanced non-small cell lung cancer to 6.8 months versus 4.4 months with chemotherapy plus placebo. The hazard ratio of 0.52 indicates a markedly reduced risk. The data are likely to affect clinical assessment and market expectations for Summit Therapeutics. » More on finanzen.net