Celldex Therapeutics

Celldex Therapeutics’ stock rose to a 52-week high of $40.30, giving it a market capitalization of about $3.16 billion; the share has gained 73% over six months and 86.85% year to date. InvestingPro currently rates the stock as overvalued versus its fair value. At the same time, Celldex has discontinued the Phase II study of barzolvolimab in prurigo nodularis after failing to meet the primary and key secondary endpoints, prompting differing analyst price targets (Canaccord slightly lowered, Guggenheim raised, UBS reiterated). Chief Financial Officer Sam Martin announced he will retire in March 2027. » Altro su de.investing.com

Celldex reported that the phase‑2 trial of barzolvolimab in prurigo nodularis did not meet the primary and key secondary endpoints, sending the stock sharply lower in after‑hours trading. Barzolvolimab markedly reduced mast cells and serum tryptase but showed no significant improvement in itch or skin lesions versus placebo. Celldex is discontinuing the prurigo nodularis study, emphasizes a favorable safety profile, and will continue developing barzolvolimab in other indications; Phase‑3 topline data for chronic spontaneous urticaria are expected in Sep/Oct 2026. » Altro su de.investing.com

Shares of Celldex Therapeutics climbed to a new 52-week high of $39.16, having nearly doubled from a low of $19.72 and bringing market capitalization to about $3.07 billion. Investor confidence is supported by positive clinical data, including promising Phase 1 results for CDX-622 and continued improvements with barzolvolimab in angioedema. Several analysts raised their valuations or maintained buy ratings (UBS: Buy; Wells Fargo: Overweight with a $54 target; Barclays: upgraded to Overweight), while InvestingPro rates the stock as overvalued relative to its fair value. » Altro su de.investing.com