COMPASS THERAP. DL-,0001 Aktie

Compass Therapeutics released phase 1 data on CTX-8371, a bispecific antibody targeting PD-1 and PD-L1, showing three responses among 15 evaluable patients, including a >90% reduction in a case of triple-negative breast cancer. In the two highest dose cohorts (3.0 and 10.0 mg/kg) the overall response rate was 33% (2 of 6). No dose-limiting toxicities were observed; adverse events were mostly grade 1–2, with one asymptomatic grade 3 lipase elevation. The company has expanded cohorts for NSCLC, triple-negative breast cancer and Hodgkin lymphoma; additional data are expected in Q4 2026 and the results will be presented on May 30, 2026 at ASCO. Despite the clinical progress, the stock remains under pressure (market cap $326m, YTD loss 65% near a 52-week low) and investors are concerned about rapid cash burn. » Altro su de.investing.com

Compass Therapeutics’ shares plunged 80% after the Phase II/III COMPANION-002 study of tovecimig plus paclitaxel in cholangiocarcinoma produced mixed results. Progression-free survival showed high statistical significance, but the overall survival endpoint was not met. The company and analysts say the OS result was affected by frequent crossover of control patients into the tovecimig arm (54%), raising questions about the dataset’s suitability for FDA approval. A pre-BLA meeting in mid‑2026 is expected as the next key milestone, and investors anticipate continued volatility. » Altro su de.investing.com

Compass Therapeutics reports that the combination of Tovecimig and Paclitaxel in the COMPANION-002 study met the secondary endpoint of progression-free survival (median PFS 4.7 vs. 2.6 months) with a hazard ratio of 0.44. The primary endpoint ORR was previously significant at 17.1% vs. 5.3%; overall survival did not reach significance, influenced by a 54% crossover in the control arm. Common adverse events included hypertension, fatigue and neutropenia; Compass plans a meeting with the FDA before a planned regulatory submission and will present the full data at a conference. » Altro su de.investing.com