ProMIS Neurosciences

At the Cantor Fitzgerald Healthcare Conference, ProMIS emphasized that blinded interim results from the PRECISE‑AD study showed a favorable biomarker signal and no occurrence of ARIA‑E. The company sees a strong early safety profile for the monoclonal antibody PMN310 and expects the full 12‑month data from 128 patients in Q1 2027. ProMIS says it is funded through the end of 2027 and could, if the 12‑month results are convincing, move directly into a registration‑enabling phase‑3 trial; partnerships or self‑funding remain options. » Więcej na de.investing.com

ProMIS Neurosciences stock rose 16.1% in premarket trading after the presentation of six‑month, blinded interim results from the phase‑1b PRECISE‑AD study of PMN310. Among 136 patients there were no ARIA‑E cases; the overall incidence of ARIA was 4.4% and was limited to mild, asymptomatic microbleeds. There were no treatment‑related serious adverse events or study‑related discontinuations. The data are viewed as strong evidence of safety, particularly in APOE4 carriers, and were accompanied by new analyst coverage (Chardan: buy, price target $20.00), which drove the share price from $11.72 to $13.61. » Więcej na de.investing.com

ProMIS Neurosciences is hosting a webinar to discuss the blinded six-month interim results of the PRECISE-AD Phase 1b study for PMN310. Discussions will focus on aggregated safety data and trends in selected biomarkers from patients with early-stage Alzheimer’s. PMN310 is a humanized monoclonal IgG1 antibody that targets toxic amyloid‑beta oligomers without binding to plaques or vascular deposits, potentially reducing the risk of amyloid-related imaging abnormalities. The randomized, double-blind study of 144 participants across three dose cohorts is fully recruited; PMN310 received FDA Fast-Track designation in July 2025. » Więcej na de.investing.com