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Quoin reports positive interim results for QRX003 in Netherton syndrome

Quoin reports from the phase 2/3 study of 4% lotion QRX003: in an interim analysis of six patients, four of six participants (66.7%) reached the primary endpoint of at least a one‑grade improvement on the Investigator Global Assessment scale at 12 weeks (p=0.0087). The key secondary endpoint (Global Impression of Change) was also statistically significant (p=0.0070). Patients showed marked improvements in itch and in the Ichthyosis Area and Severity Index (reductions 31–87%); no treatment‑related serious adverse events or clinically significant abnormalities were reported. The study aims to enroll about 20 participants, with recruitment expected to be completed by the end of 2026 and topline data anticipated in Q2 2027; QRX003 has FDA orphan, Rare Pediatric Disease and Fast Track designations. » More on de.investing.com