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Denifanstat (ASC40), a once-daily oral fatty acid synthase (FASN) inhibitor, demonstrated statistically significant and clinically meaningful improvement compared to placebo in all primary, key secondary, and secondary endpoints Denifanstat demonstrated a favorable safety and tolerability profile Denifanstat was 98% and 178% more effective than U.S. Food and Drug Administration (FDA)-approved sarecycline and doxycycline with regard to placebo-adjusted percent treatment success, respectively, 18.6% for denifanstat versus 9.4% for sarecycline, 18.6% versus 6.7% for doxycycline Denifanstat was 60% more effective than FDA-approved clascoterone cream with regard to placebo-adjusted percent treatment success, 18.6% for denifanstat versus 11.6% for clascoterone cream, respectively The exceptional efficacy of denifanstat coupled with its favorable safety profile in the Phase III trial provides a potential major break-through for the treatment of acne HONG KONG , June 3, 2025 /PRNewswire/ -- Ascletis Pharma Inc. (HKEX: 1672, "Ascletis") announces today that denifanstat (ASC40), a first-in-class, once-daily oral small molecule fatty acid synthase (FASN) inhibitor, meets all primary, key secondary, and secondary endpoints in the Phase III clinical trial for the treatment of moderate to severe acne vulgaris (NCT06192264). The Phase III clinical trial was a randomized, double-blind, placebo-controlled, multicenter clinical trial in China to evaluate the safety and efficacy of denifanstat once-daily oral tablet in 480 patients with moderate to severe acne vulgaris.» Mehr auf prnewswire.com

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Asia Pacific Opportunity Zone Project was Presented to Houston Mayor John Whitmire at International Trade Center Conference HOUSTON, TX / ACCESS Newswire / May 27, 2025 / ASC Global Inc. as a wholly-owned subsidiary of Token Communities (OTC PINK:TKCM) presented APOZ Project to Mayor John Whitmire at the ITC ( International Trade Center ) Inauguration Ceremony of the Board of Directors on on May 23, 2025. Ms. Tina Pei Wise who is the Director of Coordination of ASC Global Inc. ( the developer of the APOZ Project ) was elected as the Vice President of ITC ( International Trade Center ) in Houston, Texas, Ms.» Mehr auf accessnewswire.com